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Open Access Highly Accessed Review

Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers

Oluwole Fadare12* and Wenxin Zheng34

Author Affiliations

1 Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas, USA

2 Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

3 Department of Pathology, Department of Obstetrics and Gynecology, and the Arizona Cancer Center, University of Arizona College of Medicine, Tucson, Arizona, USA

4 Department of Pathology and Hospital of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China

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Diagnostic Pathology 2008, 3:6  doi:10.1186/1746-1596-3-6

Published: 8 February 2008

Abstract

In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.