Table 2

Expression of EBV and Topo II∝ in the normal oral tissues, oral epithelial dysplasia and oral squamous cell carcinomas

HISTOLOGY

Number of cases

EBV expression(%)^(a)

P-value

Topo II-∝ LI (%)^(b)

P-value

NSE

20

0.000 ± 0.000

d

5.35 ± 2.22

c

OED

16

25.6 ± 25.38

14.08 ± 2.99

Mild

7

13.43 ± 13.24

NS

12.27 ± 2.17

NS

Moderate

5

24.00 ± 22.62

13.50 ± 1.86

Severe

4

48.75 ±

17.98 ± 1.51

OSCC

22

41.79 ± 29.31

27.56 ± 7.49

W-scc

10

36.09 ± 22.37

22.40 ± 3.19

M-scc

8

41.15 ± 33.18

NS

28.54 ± 4.84

e

P-scc

4

57.33 ± 38.91

39.00 ± 6.45

NSE, normal squamous epithelium; OED, OraLepithelial dysplasia; OSCC, oral squamous cell carcinoma; NS, not significant.

^a mean ± standered deviation of EBV

^b mean ± standered deviation of Topo II-α LI.

^c NSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P = 0.083.

^dNSE vs. OED P < 0.001;NSE vs. SCC, P < 0.001; OED vs. SCC, P < 0.001.

^eW-SCC vs. M-SCC, P = 0.008; W-SCC 1 vs.P-SCC, P = 0.001; W-SCC vs. M-SCC +P-SCC, P < 0.001.

Shamaa et al. Diagnostic Pathology 2008 3:45   doi:10.1186/1746-1596-3-45