The heterogeneity of breast tumor cell populations. The heterogeneity of breast cancer cells was demonstrated with brightfield double in situ hybridization (BDISH) stained tissue sections. In general, there were 2 types of the tumor cell heterogeneity: 1) variegated tumor populations of, as an example, non-amplified (blue asterisk) and amplified (yellow asterisk) HER2 gene cells in the same area (A) and 2) segregated tumor populations of, as an example, discrete (B) and clustered (C) HER2 gene cells in different areas. The tumor cell heterogeneity with different appearance of HER2 and CEN 17 is also seen among the non-large clustered HER2 cells (B). 100×.
Nitta et al. Diagnostic Pathology 2008 3:41 doi:10.1186/1746-1596-3-41