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Open Access Case Report

Multicystic urothelial carcinoma of the bladder with gland-like lumina and with signet-ring cells. A case report

Isabel Alvarado-Cabrero1, Delia Pérez-Montiel2 and Ondrej Hes3*

Author Affiliations

1 Department of Pathology, Mexican Oncology Hospital, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico

2 Department of Pathology, Instituto Nacional de Cancerologia (INCan) Av. San Fernando #22 Tlalpan, 14080 Mexico City, Mexico

3 Department of Pathology, Laboratore Spec. Diagnostiky, Medical Faculty Hospital, Alej Svobody 80, 323 18 Pilsen, Czech Republic

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Diagnostic Pathology 2008, 3:36  doi:10.1186/1746-1596-3-36

Published: 3 September 2008


We present the case of 80-year-old male with superficial papillary urothelial carcinoma of the urinary bladder with striking multicystic architecture with a combination of features of urothelial carcinoma with gland-like lumina, with signet-ring cell differentiation and microcystic pattern. However, the tumor shared the morphologic features of several variants of urothelial carcinoma, the most important differential diagnosis covered so-called florid Brunneriosis, cystitis cystica, and primary adenocarcinomas of the urinary bladder.