Lymphangioma-like Kaposi sarcoma. A. Low-power photomicrograph depicting the upper dermal expansion by a proliferation that is distinctly reminiscent of a lymphatic neoplasm or malformation. Note the reactive epidermal hyperplasia and hyperkeratosis (H&E stain). B. Closer view of the "lymphangiomatous" proliferation, with each gaping channel lined by a monolayer of plump Kaposi sarcoma cells, and frothy, pale eosinophilic intraluminal fluid resembling lymph (H&E stain). C. Positive staining of lining cells with the lymphatic endothelial marker D2-40. D. Nuclei of the same cellular population show immunoreactivity for LNA-1.
Grayson and Pantanowitz Diagnostic Pathology 2008 3:31 doi:10.1186/1746-1596-3-31