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Open Access Highly Accessed Review

Histological variants of cutaneous Kaposi sarcoma

Wayne Grayson1 and Liron Pantanowitz2*

Author Affiliations

1 Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa

2 Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts, USA

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Diagnostic Pathology 2008, 3:31  doi:10.1186/1746-1596-3-31

Published: 25 July 2008

Abstract

This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.