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Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions

Amanjit Bal1*, Kusum Joshi1, Rajesh Logasundaram1, BD Radotra1 and Rajinder Singh2

Author Affiliations

1 Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

2 Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Diagnostic Pathology 2008, 3:23  doi:10.1186/1746-1596-3-23

Published: 30 May 2008



Nm23 protein is a metastasis suppressor protein, expressed in all tissues. Reduced Nm23 expression is related to a high incidence of lymph node and distant metastasis and poor prognosis in patients with cancers. The present study was done to analyze the expression of Nm23 using immunohistochemistry in non-neoplastic and neoplastic breast lesions.


Sections from 93 samples were studied and classified into non-proliferative breast lesion (13), fibrodenoma (7), proliferative breast lesion (13), carcinoma in situ (20), invasive carcinoma (23) and metastatic deposits in lymph nodes (17).


Nm23 expression in these groups showed a progressive down regulation with increasing neoplastic transformation. On comparing the various groups, nm23 expression was significantly different between the various subgroups with greatest expression in non-proliferative lesions and least in metastatic deposits (p < 0.050).


It is concluded that the modulation of nm23 in a spectrum of breast lesions can be indicative of metastatic phenotype and help to predict the aggressiveness of disease.