Lymph node biopsy. Biopsy of the enlarged lymph node revealed an intact capsule and obliterated sinuses. A diffuse infiltrate effaced the normal nodal architecture (Upper left panel, hematoxylin and eosin, original magnification ×100). The infiltrate was composed of an admixture of small lymphocytes, macrophages, and plasma cells (Upper right panel, hematoxylin and eosin, original magnification ×400). The infiltrate was composed of a mixture of CD3 positive T-cells (including both CD4 and CD8 positive cells) and CD20 positive B-cells. Numerous macrophages were also CD4 positive (Original magnification ×400).
Hurley et al. Diagnostic Pathology 2008 3:13 doi:10.1186/1746-1596-3-13