Induction of distinct gene expression patterns in lymphoid and epithelial cells by the BARF-1 gene of Epstein-Barr virus

A Zur Hausen¹, T Wiech¹, E Nikolopoulos¹, S Lassmann¹, T Heidt¹, M Sarbia², A Walch², M Werner¹ and T Ooka³

¹Institut für Pathologie, Universitätsklinikum Freiburg, Germany

²Technische Universität München, Institut für Pathologie, Germany

³Université Claude Bernard Lyon, Laboratoire de Virologie Moléculaire, Lyon, France

corresponding author email

from 35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR)
The Institute of Pathology, University Hospital Freiburg, Germany. 1 July 2006

Diagnostic Pathology 2007, 2(Suppl 1):S9doi:10.1186/1746-1596-2-S1-S9


Published:	14 March 2007

First paragraph (this article has no abstract)

The expression of the BARF1 gene of Epstein-Barr virus (EBV) in latent EBV infection is restricted to epithelial malignancies, e.g. gastric carcinomas (GC) or nasopharyngeal carcinomas (NPC). In addition, BARF1 is considered to be a lytic gene because it is expressed upon induction of the lytic cycle in Burkitt's lymphoma cell lines.