This article is part of the supplement: 35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR) .

Oral presentation

Glypican 3 expression in human normal and neoplastic tissue: a tissue microarray analysis on 4338 tissue samples

D Baumhoer, LM Terracciano, S Stadlmann and L Tornillo

Institut für Pathologie, Universität Basel, Switzerland

corresponding author email

from 35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR)
The Institute of Pathology, University Hospital Freiburg, Germany. 1 July 2006

Diagnostic Pathology 2007, 2(Suppl 1):S5doi:10.1186/1746-1596-2-S1-S5

Published:	14 March 2007

First paragraph (this article has no abstract)

Glypican 3 (GPC3) belongs to the glypican family of GPI anchored heparan sulfate proteoglycans, which play a crucial role in cellular growth, cell migration and cell differentiation. Several studies have shown GPC3 to be a highly specific marker for hepatocellular carcinoma (HCC) and for differentiating non- and pre-neoplastic liver disease. To systematically investigate the epidemiology of GPC3 expression in non-neoplastic, pre-neoplastic and neoplastic tissues, we used tissue microarray (TMA) technology to analyze the immunohistochemically detectable expression of GPC3 in 3,678 tissue samples from 132 different tumor categories and 31 non-neoplastic and pre-neoplastic tissue types.