This article is part of the supplement: 35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR)

Oral presentation

HPV E6/E7 mRNA transcripts as predictors of high-grade epithelial cervix dysplasia

J Möckel¹, A Clad², A-S Endres³ and V Schneider⁴

¹Institut für Pathologie, Klinikum Lahr, Germany

²Universitäts-Frauenklinik Freiburg, Germany

³Institut für Virologie, Charite Universitätsmedizin, Berlin, Germany

⁴Pathologisches Institut Dr. Schneider, Freiburg, Germany

corresponding author email

from 35te Tagung der Pathologen am Oberrhein/35th Meeting of Pathologists of the Upper Rhine Region (PATOR)
The Institute of Pathology, University Hospital Freiburg, Germany. 1 July 2006

Diagnostic Pathology 2007, 2(Suppl 1):S1doi:10.1186/1746-1596-2-S1-S1

Published:	14 March 2007

First paragraph (this article has no abstract)

Detection of E6 and E7 mRNA transcripts has been shown to be of higher prognostic value for the evaluation of the precursor lesions of cervical carcinoma than the detection of HPV DNA in a number of pilot studies [1-3]. In particular in low grade lesions, HPV DNA testing has poor discriminating power as to the progression of CIN, thus leading to considerable overtreatment with ensuing costs to the health care system. We tested an E6, E7 mRNA detection system in a multicenter study in Germany for its usefulness in clinical practice.