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Open Access Case Report

Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature

Luis F Gonzalez-Cuyar1, Fabio Tavora1, Allen P Burke1, Christopher D Gocke14, Ann Zimrin2, John J Sauk3 and Xiafeng F Zhao1*

Author affiliations

1 Department of Pathology, University of Maryland School of Medicine, 22 South Greene Street, NBW64, Baltimore, Maryland, USA

2 Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, NBW64, Baltimore, Maryland, USA

3 Department of Oral Pathology, University of Maryland School of Medicine, 22 South Greene Street, NBW64, Baltimore, Maryland, USA

4 Departments of Pathology and Oncology, Johns Hopkins School of Medicine, Baltimore MD, USA

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Citation and License

Diagnostic Pathology 2007, 2:49  doi:10.1186/1746-1596-2-49

Published: 19 December 2007

Abstract

Background

Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.

Methods

Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.

Results

The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.

Conclusion

This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.