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Open Access Short report

Floret-like multinucleated giant cells in neurofibroma

Sameer Singh Shaktawat1* and Dariusz Golka2

Author affiliations

1 Department of Histopathology, Central Manchester and Manchester Children's University Hospital NHS Trust, Manchester, UK

2 Department of Histopathology, Blackpool Victoria Hospital, Blackpool, UK

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Citation and License

Diagnostic Pathology 2007, 2:47  doi:10.1186/1746-1596-2-47

Published: 8 December 2007

Abstract

This short report discusses a case of neurofibroma containing floret-like multinucleated giant cells. This being the second such case in the literature. Floret-like multinucleated giant cells have been reported in gynaecomastia and neurofibroma in neurofibromatosis type 1. These cells have been reported in uncommon soft tissue tumours including pleomorphic lipoma, giant cell collagenoma, giant cell fibroblastoma and giant cell angiofibroma. We recommend these cells to be interpreted carefully keeping in mind the rare malignant change in neurofibromas. Immunohistochemistry would help in defining the nature of such cells.