Figure 4.

Histologic findings of CMF obtained from resected surgical specimen (case no. 2). (A) Well circumscribed lobules of loose chondroid and myxoid tissue delineated by hypercellular fibrous septae containing bland fibroblasts (H&E, ×4). (B) Characteristic zoned hypercellular areas with osteoclast-like giant cells surrounding chondroid and myxoid areas (H&E, ×10). (C) Chondroid and myxoid matrix containing anastomosing strands of spindle and stellate cells with bland nuclei, finely dispersed chromatin, and inconspicuous nucleoli (H&E, ×20). (D) Hypercellular area containing plump mononuclear cells resembling chondroblasts, and admixed with multinucleated giant cells resembling osteoclasts (H&E, ×40).