A unique RET EXON 11 (G691S) polymorphism in an Indian patient with a collision tumor of the thyroid
1 Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, 400012, India
2 Tata Memorial Hospital, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, 400012, India
3 Tata Memorial Hospital, Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra, 400012, India
Diagnostic Pathology 2007, 2:39 doi:10.1186/1746-1596-2-39Published: 16 October 2007
Collision tumors of the thyroid are rare, with occasional reports dealing with their genetic analysis.
A 59 year old lady presented with a neck mass, associated with hoarseness of voice of 5 years duration. Radiological examination revealed nodular masses in the left lobe of her thyroid, along with one in the isthmus, extending into the right lobe and associated with enlarged neck nodes. FNAC from the left thyroid showed features of medullary carcinoma. On total thyroidectomy, 2 distinct tumor nodules were identified in the left lobe with another in the isthmus, showing features of medullary carcinoma (MTC), papillary carcinoma and follicular variant of papillary carcinoma, respectively, accompanied with nodal metastasis. Subsequently, she underwent radioablation. RET gene analysis of the patient, her 2 daughters and a grandson revealed a unique G691S polymorphism on Exon 11.
This unique case of a collision tumor of thyroid, including component of an MTC deals with the value of RET gene analysis and therapeutic implications in the index case and in family members.