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Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chonic lymphocytic leukemia/small lymphocytic lymphoma: case report

Dina El Demellawy1, Catherine Ross2, Monalisa Sur2 and Salem Alowami2*

Author Affiliations

1 Northern Ontario School of Medicine, Department Of Pathology and Laboratory Medicine, West Campus, Thunder Bay, Ontario, Canada

2 McMaster University, Department Of Pathology and Molecular Medicine, Hamilton, Ontario, Canada

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Diagnostic Pathology 2007, 2:34  doi:10.1186/1746-1596-2-34

Published: 30 August 2007


Synchronous composite tumors have been described but are uncommon. Moreover, simultaneous occurrence of synchronous tumors in the same tissue or organ is even less common. We report a case of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma and malignant melanoma (MM) occurring synchronously in the same lymph node. Several cases of an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of which included CLL and MM, occurring in the same patient often CLL after MM. The risk of having CLL after MM has been reported to be increased. Various genetic and environmental etiologies have been postulated, but have as yet not been proven. To our knowledge this is the first time that synchronous occurrence of these two malignant processes in the same tissue is described. In this case it is important that the melanoma was recognized in the excised lymph node, as this finding had much more critical treatment and long term survival consequences.