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Open Access Case Report

Composite Multifocal Basal Cell carcinoma and Precursor B Acute Lymphoblastic Leukemia: Case report

Dina El Demellawy1, Monalisa Sur2, Catherine Ross2, Franco DeNardi2 and Salem Alowami2*

Author Affiliations

1 Northern Ontario School Of Medicine, Department Of Pathology and Laboratory Medicine, West Campus, Thunder Bay, Ontario, Canada

2 McMaster University, Department Of Pathology and Laboratory Medicine, Hamilton, Ontario, Canada

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Diagnostic Pathology 2007, 2:32  doi:10.1186/1746-1596-2-32

Published: 23 August 2007

Abstract

Synchronous composite tumors though described are uncommon. Moreover, simultaneous occurrence of synchronous tumors involving the same tissue or organ at multiple sites is even less common. We report a case of acute lymphoblastic leukemia (ALL) and basal cell carcinoma (BCC) occurring simultaneously in multiple skin sites. Several cases showing an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of these cases included ALL and BCC and occurred often in the pediatric population with the BCC arising as a post-ALL therapy sequela. Other rare genetic causes may be considered. To our knowledge this is the first time that the synchronous occurrence of these two malignant processes in the same tissue involving multiple sites in an elderly patient is described.