Table 2

Pathologic characteristics of primary carcinoid tumor arising within mature teratoma of the kidney

Source, year

Macroscopic findings

Components of Mature Teratoma

Architectural patterns of carcinoid tumor

Cytologic features of carcinoid tumor

Mitotic rate of carcinoid tumor*

Immuno-phenotype of carcinoid tumor*


Side/Gross

Site/Size, cm


Kojiro et al, 1976 [2]

Left/Polycystic with smooth and nodular external surface

NP/17

Mucous secretory glands, columnar epithelium, mature hyaline cartilage, smooth muscle

NP

Finely granular eosinophilic cytoplasm, uniform rounded nuclei with coarse chromatin and small nucleoli

0/10 HPF

NP

Fetissof et al, 1984 [3]

Right/Dilated sac filled with purulent exudate in horseshoe kidney with lower poles connected by broad isthmus

NP/2

Transitional and mucinous columnar epithelium with occasional cilia, smooth muscle, ossified chondroid plaques, nerve bundles with ganglion cells

Anastomosing ribbons intermixed with solid nests

NP

NP

SER+, GLU+, SOM+, ACTH-, CAL-, GAS-, INS-, MOT-, NEU-

Lodding et al, 1997 [1]

Right/Gray-white firm nodule in horseshoe kidney with broad connecting bridge in midline

Lower pole/2

Mature bone

Organoid

Uniform cells

NP

PCK+, NSE+, CHR+, SYN+, S-100+, SER+, PSA-

Yoo et al, 2002 [4]

Left/Well circumscribed, tan-pink, glistening, focally hemorrhagic, primarily solid

Lower pole/3.5

Mucinous tall columnar epithelium, mature smooth muscle, mature bone

Anastomosing ribbons intermixed with solid nests

Monotonous small cells with finely stippled chromatin and inconspicuous nucleoli

0/10 HPF

PCK+, NSE+, CHR+

Kim et al, 2004 [5]

Right/Well defined solid, yellowish tan

Upper and mid poles/3.5

Mucinous columnar and pseudostratified columnar epithelium with occasional cilia, mature bone

Trabecular and anastomosing ribbons or nests

NP

NP

PCK+, NSE+, CHR+, SYN+

Kurzer et al, 2005 [6]

Right/Cyst filled with tan-brown friable material and three irregular tan-brown stones

Mid-lower pole/1

Transitional, colonic, squamous, and non-specific cuboidal epithelium, mature adipose, focal osseous metaplasia

Nests and cords

Small cells with peripheral palisading

NP

CHR+

Current case

Right/Cyst with irregular pale tan wall and focal calcifications

Middle pole/2

Urothelial-type and colonic epithelium, focal mature bone

Trabecular and anastomosing ribbon-like nests

Monotonous small round cells with peripheral palisading, and "salt-and-pepper" chromatin pattern

0/10 HPF

SYN+, CD 56+, PCK+, THY+, CK 7-, CK 20-, CAR-, PR-, ER-, S-100-, Melan-A-, INS-, TTF-1-, CHR-,


*NP, not provided; HPF; high power field; SYN, synaptophysin; PCK, pancytokeratin; THY, thyroxine; CK, cytokeratin; CAR, calretinin; PR, progesterone receptor; ER, estrogen receptor; INS, insulin; TTF, thyroid transcription factor; CHR, chromogranin; NSE, neuron specific enolase; SER, serotonin; PSA, prostate specific antigen; GLU, glucagon; SOM, somatostatin; ACTH, adrenocorticotropic hormone; CAL, calcitonin; GAS, gastrin; MOT, motilin; NEU, neurotensin

Armah and Parwani Diagnostic Pathology 2007 2:15   doi:10.1186/1746-1596-2-15

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