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Open Access Research

Mast cell density in gastric biopsies of pediatric age group and its relation to inflammation and presence of Helicobacter pylori

Fatemeh E Mahjoub1*, Behnam Hassanbeglou1, Zahra Pourpak2, Fatemeh Farahmand3, Nasim Kashef2 and Atousa Azam Akhlaghi4

Author Affiliations

1 Pathology Department, Children Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

2 Immunology, Asthma and Allergy Research Institute, Children Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

3 Gastroenterology Department, Children Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

4 Nutrition Department, Children Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

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Diagnostic Pathology 2007, 2:14  doi:10.1186/1746-1596-2-14

Published: 12 May 2007

Abstract

Background

The aim of this study was to investigate the relationship between mast cell density, histological severity of gastritis, and presence of Helicobacter pylori (H. pylori) in the antral mucosa of pediatric patients.

Methods

The study included 352 (192 male and 160 female, < 14 years old) patients. All cases underwent endoscopy, and biopsies were obtained for histopathological examination and evaluation of Helicobacter pylori. All biopsies were evaluated according to the Sydney system and mast cell density in the antral mucosa was analyzed by Giemsa stain. Spearman's correlation test was used to determine the relationship between mast cell density and other histopathological parameters. The comparison of mast cell density between H. pylori positive and negative groups was analyzed by Mann Whitney U test.

Results

Mast cell density was 12.6 ± 0.87 in 0.25 mm2 (0–81). Means of severity of gastric inflammation in H. pylori-positive and negative patients were 1.7 ± 0.6 and 0.6 ± 0.7, respectively, which was statistically significant (p = 0.0001). Mast cell density was not correlated with presence and degree of inflammation, activity, presence and score of H. pylori in the antrum (p > 0.05). There was no significant correlation between mast cell density and allergy.

Discussion

We concluded that there may be some other ways for contribution of mast cells in pathologic processes involving gastrointestinal tract in children.