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Malignancy in the blind painful eye – report of two cases and literature review

Patrícia Rusa Pereira12, Alexandre Nakao Odashiro1234*, João Pessoa Souza Filho12, Vinicius S Saraiva12, David Gerardo Camoriano2 and Miguel N Burnier2

Author Affiliations

1 Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil

2 Henry C. Witelson Ocular Pathology Laboratory, Department of Ophthalmology McGill University, Montreal, Canadá

3 LAC, Pathology and Cytopathology Laboratory, Campo Grande, MS, Brazil

4 Universidade para o Desenvolvimento do Estado e Região do Pantanal, UNIDERP, Campo Grande, MS, Brazil

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Diagnostic Pathology 2006, 1:45  doi:10.1186/1746-1596-1-45

Published: 21 November 2006



Few cases of malignant tumors arising in a blind painful eye have previously been described. We described two cases of a blind painful eye containing an unsuspected tumor, which were enucleated to relieve the pain.

Case presentations

Case 1: A 57 year-old Caucasian man presented with recurrent orbital cellulitis and endophthalmitis in the left eye (OS). The OS was blind and painful and an enucleation was performed showing a uveal melanoma by histopathological exam. Case 2: A 54 year-old Caucasian man with previous history of a rhegmatogenous retinal detachment in his left eye presented a blind painful eye. Enucleation was performed revealing a well-differentiated B-cell lymphoma of uveal tract with extra ocular extension.


In the management of a blind painful eye, it is extremely important to rule out an intraocular malignancy particularly in those patients who have not been followed by an ophthalmologist.