Table 1

Prognostic factors associated with prostate cancer after different types of treatment and according to the level of extension. Patients with organ confined disease treated with radical prostatectomy (surgical or radiated), and patients with more extensive disease are presented separately. The database applied was PubMed, the presented papers were published during years 1989 – 2005.

Organ confined disease, radical prostatectomy (surgical)


    Survival-associated prognosticators

    Progression-associated prognosticators

Prognosticator

p value

Reference

Prognosticator

p value

Reference

Tumour volume

< 0.009

Salomon et al.

Age

< 0.01

Obek et al.

Gleason score

< 0.0002

Hoznek et al.

Gleason score

< 0.0001

Epstein et al.

Surgical margin

< 0.009

Hoznek et al.

Capsular invasion

< 0.001

Wheeler et al.

Tranzitional zone

< 0.04

Augustin et al.

PSA*

< 0.001

Salomon et al

p53

< 0.011

Kuczyk et al.

Surgical margin

< 0.075

Bloom et al.

Stage

< 0.02

Kuczyk et al.

E-cadherin

< 0.005

Umbas et al.

p27

< 0.01

Yang et al.

IGF-1**

< 0.05

Yu et al.

Aneuploidy

< 0.02

Zincke et al.

Stage

< 0.001

D'Amico et al.

Ki-67

< 0.001

Bettencourt et al.

MVD***

< 0.007

Halvorsin et al.

cDNA microarray

< 0.01

Susan et al.

p27

< 0.008

Yang et al.

Aneuploidy

< 0.0001

Zincke et al.

Aneuploidy

< 0.001

Ross et al.

Ki-67

< 0.02

Bubendorf et al.

MUC1

< 0.003

Lapointe et al.

Organ confined disease, radical prostatectomy (radiation)


    Survival-associated prognosticators

    Progression-associated prognosticators

Prognosticator

p value

Reference

Prognosticator

p value

Reference

Age

< 0.02

Austin el al.

Age

< 0.01

Neulander et al

Race

< 0.02

Austin et al.

Gleason score

< 0.001

Kupelian et al.

p53

< 0.02

Grignon et al.

Radiation dose

< 0.001

Kupelian et al.

Prostate cancer with extension outside the prostate (advanced disease)


    Survival-associated prognosticators

    Progression-associated prognosticators

Prognosticator

p value

Reference

Prognosticator

p value

Reference

AR****

< 0.01

Segawa et al.

Nuclear morphometry

< 0.01

Partin et al.

AR

< 0.02

Miyoshi et al.

Nuclear morphometry

< 0.0003

Vesalainen et al.

Total-PSA

< 0.001

Bjork et al.

Gleason score

< 0.0001

Vesalainen et al.

MVD

< 0.0001

Borre et al.

Gleason score

< 0.007

Shurbaji et al.

Ki-67

< 0.02

Aaltomaa et al.

AR

< 0.03

Sadi et al.

p53

< 0.018

Bauer et al.

bcl-2

< 0.004

Bauer et al.


* Prostate Specific Antigen, ** Insulin-like Growth Factor, *** Microvessel density, **** Androgen Receptor

Buhmeida et al. Diagnostic Pathology 2006 1:4   doi:10.1186/1746-1596-1-4

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