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Open Access Highly Accessed Case Report

Radiation-induced leiomyosarcoma of the oropharynx

Jens Pfeiffer1*, Carsten Christof Boedeker1, Gerd Jürgen Ridder1, Wolfgang Maier1 and Gian Kayser2

Author Affiliations

1 Department of Otorhinolaryngology – Head and Neck Surgery, Freiburg Medical School, Freiburg, Germany

2 Institute of Pathology, Freiburg Medical School, Freiburg, Germany

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Diagnostic Pathology 2006, 1:22  doi:10.1186/1746-1596-1-22

Published: 22 August 2006

Abstract

Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international literature, radiation-induced sarcoma arise in 0.035 to 0.2 % of all irradiated patients. Especially in the head and neck region, radiation-induced leiomyosarcoma is an extremely rare lesion. The authors report a case of a radiation-induced leiomyosarcoma of the tonsillar region of the oropharynx in a 51-year-old male patient, who had undergone radiation therapy of this region 38 years before. The lesion was treated by radical surgery. Diagnostic steps, histological presentation and therapy are described in detail and the literature concerning radiation induced malignancies in general as well as radiation induced leiomyosarcoma in particular is reviewed. The highlights of this case are an extremely uncommon location and a rare pathological entity of radiation induced malignancies.