Figure 2.

Distinct types of EGFR gene amplification identified in non-small cell lung carcinomas using the EGFR SpectrumOrange/CEP 7 SpectrumGreen FISH probe (Vysis/Abbott Molecular): A. Large EGFR gene clusters; B. Co-localized clusters of EGFR and CEP7 signals; C. Large and bright EGFR signal, larger than the CEP 7 signals in tumor cells; D. High frequency of balanced EGFR and CEP 7 signals.