Table 1 |
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|
Previously reported cases of morphologically pure adenoid basal lesions in the English literature. |
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|
Authors (reference) |
No of patients |
age (yrs) |
Race |
Presentation/pap smear findings |
Gross or pelvic examination findings |
Associated cervical intraepithelial dysplastic lesion |
Diagnostic and/or Therapeutic measure(s) |
Lymph node status |
Follow-up, (months) |
|
|
|
||||||||||
|
1 |
Baggish & Woodruff [24]*** |
1 |
63 |
white |
Vaginal bleeding/NR |
Atrophic vaginal mucosa; NCF |
CIS |
Hysterectomy/BSO |
NPR |
NED 156 |
|
2 |
1 |
62 |
black |
Uterine prolapse/NR |
NCF |
CIS |
Hysterectomy |
NPR |
NED 84 |
|
|
3 |
1 |
39 |
black |
Abnormal pap smear |
NR |
CIS |
Conization/Hysterectomy |
NPR |
NED 60 |
|
|
4 |
Baggish & Woodruff [23] |
1 |
60 |
white |
"incidental"/negative |
NCF |
None |
Hysterectomy/BSO |
NPR |
NED 6 |
|
5 |
Cases 1–3 |
1 |
80 |
white |
"incidental"/negative |
NCF |
None |
Hysterectomy/BSO |
NPR |
NED 6 |
|
6 |
1 |
80 |
black |
Lower abdominal pressure/negative |
Cervical eversion |
CIS |
Conization/Hysterectomy/BSO |
NPR |
NED 6 |
|
|
7 |
Russell & Laverty [22] |
1 |
62 |
NR |
uterine prolapse and vaginal bleeding/"Very Atypical cells" |
Cervical ulceration |
None |
Hysterectomy |
NPR |
NR |
|
8 |
Daroca & Dhurandhar [25], Case 3 |
1 |
60 |
NR |
Post menopausal bleeding |
Cervical erosion |
CIS |
Hysterectomy/BSO |
NPR |
NED 12 |
|
9–13 |
van Dinh & Woodrhuff [21]## |
5 |
mean 56 |
white 3, black 2 |
Vaginal bleeding n = 1, asymptomatic n = 4/moderate atypia n = 5 |
Cervical ulceration n = 1, NCF n = 4 |
CIN3 n = 3, None n = 2 |
dilatation and curettage n = 1, Hysterectomy +/- BSO n = 4 |
NPR |
DOC n = 1, NED 24–144, n = 4 |
|
14 |
Ferry & Scully [20] |
1 |
69 |
black |
Abnormal pap smear n = 11, PMB n = 2 |
NCF n = 10, cervical induration n = 2, |
CIS |
Hysterectomy/BSO |
NPR |
NED 60 |
|
15 |
Cases 1–13 |
1 |
63 |
NR |
CIS |
Hysterectomy/BSO |
NPR |
NED 120 |
||
|
16 |
1 |
66 |
black |
CIS |
Cervical excision/Rad |
NPR |
DOC 24 |
|||
|
17 |
1 |
75 |
white |
CIS |
Hysterectomy/BSO |
NPR |
NED 84 |
|||
|
18 |
1 |
65 |
asian |
CIS |
Hysterectomy/BSO/Rad |
NPR |
NED 72 |
|||
|
19 |
1 |
51 |
NR |
CIS |
Hysterectomy/BSO |
NPR |
NED 24 |
|||
|
20 |
1 |
56 |
NR |
CIS |
Cervical excision |
NPR |
NED 72 |
|||
|
21 |
1 |
78 |
white |
CIS |
Cervical excision |
NPR |
NED 72 |
|||
|
22 |
1 |
59 |
white |
CIS |
Hysterectomy/RSO |
NPR |
NED 60 |
|||
|
23 |
1 |
67 |
black |
CIS |
Hysterectomy/BSO |
NPR |
NED 48 |
|||
|
24 |
1 |
57 |
white |
CIS |
Hysterectomy/BSO |
NPR |
NED 24 |
|||
|
25 |
1 |
72 |
black |
CIS |
Conization |
NPR |
NED 29 |
|||
|
26 |
1 |
57 |
NR |
CIS |
NR |
NPR |
DOC 0 |
|||
|
27 |
Langlois et al [19] |
1 |
59 |
NR |
Asymptomatic/abnormal pap smear |
NCF |
CIN3 |
Conization, Hysterectomy |
NPR |
NR |
|
28 |
Peterson & Neumann [18] |
1 |
64 |
other |
Asymptomatic/HGSIL |
NR |
CIN2 |
Conization |
NPR |
NR |
|
29 |
Layton-Henry et al [17] |
1 |
62 |
NR |
Abnormal Pap smear n = 5/HGSIL, one with "possible invasion", n = 3; inconclusive n = 2 |
NCF |
CIN |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 1 |
|
30 |
1 |
64 |
NR |
NCF |
CIN |
Conization, Hysterectomy, BSO |
NPR |
NED 7 |
||
|
31 |
1 |
75 |
NR |
NCF |
CIN |
Conization |
NPR |
NED 15 |
||
|
32 |
1 |
60 |
NR |
NCF |
CIN |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 26 |
||
|
33 |
1 |
59 |
NR |
NCF |
CIN |
Conization, Hysterectomy, BSO, LN |
Negative |
VAIN 16 |
||
|
34 |
Powers & Frable [16] |
1 |
79 |
white |
Asymptomatic/SCC |
AWL |
CIS |
Conization, Hysterectomy BSO, LN |
Negative |
NED 18 |
|
35 |
1 |
67 |
black |
Presentation @/"severely atypical small cells" |
NCF |
None |
Conization, Rad |
NPR |
NED 16 |
|
|
36–40 |
Jones et al [13] |
1 |
Mean 51 |
white n = 5 |
abnormal pap n = 4, PMB n = 1 |
"Ulcerated, irregular indurated mass" n = 2, NCF n = 3 |
CIN 1 to3 (n = 5) |
Hysterectomy/BSO (n = 5), Hysterectomy/BSO/LN (n = 4). One patient also received Rad |
Negative |
NED 26 Mean |
|
41 |
Yoshida et al [14] |
1 |
49 |
asian |
Asymptomatic |
NCF |
CIN 3 |
Hysterectomy |
NPR |
NR |
|
42–45* |
Grayson et al [9] (Cases 4,5,7,8) |
4 |
NI |
black |
NI |
NI |
NI |
NI |
NI |
NI |
|
46 |
Brainard & Hart [10] |
1 |
91 |
NR |
Dysuria, Night sweats/HGSIL |
Focal hemorrhage |
CIS |
Conization |
NPR |
NED 4 |
|
47 |
1 |
68 |
NR |
Asymptomatic/HGSIL |
NCF |
CIS |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 5 |
|
|
48 |
1 |
78 |
NR |
Vaginal spotting/HGSIL |
NCF |
Severe dysplasia |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 15 |
|
|
49 |
1 |
30 |
NR |
Asymptomatic/HGSIL |
NCF |
Moderate severe dysplasia |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 17 |
|
|
50 |
1 |
71 |
NR |
Asymptomatic/HGSIL |
NCF |
CIS |
Conization |
NPR |
NED 21 |
|
|
51 |
1 |
67 |
NR |
Asymptomatic/HGSIL |
NCF |
Microinvasive Carcinoma## |
Conization, Hysterectomy, BSO, LN |
Negative |
NED 28 |
|
|
52 |
1 |
70 |
NR |
Dysuria, Hematuria/Negative |
NCF |
None |
Hysterectomy |
NPR |
NED 30 |
|
|
53 |
1 |
72 |
NR |
Asymptomatic/HGSIL |
NCF |
CIS |
Conization, Hysterectomy |
NPR |
NED 70 |
|
|
54 |
1 |
71 |
NR |
Asymptomatic/HGSIL |
NCF |
CIS |
Conization, BSO, Rad, LN |
Negative |
NED 82 |
|
|
55 |
1 |
76 |
NR |
NR/HGSIL |
NCF |
CIS |
Hysterectomy, BSO |
NPR |
NED 24 |
|
|
56 |
1 |
70 |
NR |
Asymptomatic/LGSIL |
NCF |
CIS |
Hysterectomy, Rad |
NPR |
NED 63 |
|
|
57 |
1 |
83 |
NR |
Asymptomatic/HGSIL |
NCF |
CIS |
Conization |
NPR |
NED 87 |
|
|
58 |
1 |
35 |
NR |
Pelvic mass@/Normal |
NCF |
None |
Hysterectomy, BSO, LN, Chemotherapy [all@] |
Negative |
NED 49 |
|
|
59 |
1 |
57 |
NR |
Asymptomatic/CIS |
NCF |
CIN |
Conization |
NPR |
NED 5 |
|
|
60 |
1 |
69 |
NR |
Asymptomatic/abnormal pap smear |
NCF |
None |
Conization |
NPR |
NR |
|
|
61 |
Senzaki et al [11] |
1 |
69 |
asian |
Vaginal bleeding |
NCF |
CIS |
Hysterectomy, BSO, LN [all@] |
Negative |
NED 6 |
|
62 |
Hiroi et al [6] |
1 |
74 |
asian |
Vaginal bleeding |
NCF |
CIN 3 |
Hysterectomy |
NPR |
NR |
|
63 |
Khoury et al [4] |
1 |
79 |
black |
Asymptomatic/HGSIL |
NCF |
Severe dysplasia |
Hysterectomy, BSO |
NPR |
NR |
|
64 |
Teramoto [2] |
1 |
69 |
asian |
Asymptomatic/HGSIL |
NR |
CIN3 |
Hysterectomy and chemotherapy@ |
NPR |
108 |
|
65 |
Zamecnik & Skrivanek [1] |
1 |
21 |
NR |
Asymptomatic//LGSIL |
NCF |
CIN1-3 |
Conization |
NPR |
NED 1 |
|
66 |
Parwani et al [1] |
1 |
65 |
NR |
NR/HGSIL |
NR |
Microinvasive Carcinoma## |
Conization, Hysterectomy, LN |
Negative |
NED 78 |
|
|
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|
Abbreviations: NED, no evidence of disease; CIS, carcinoma in situ; LN, lymph node dissection; N/A, not applicable; PMB postmenopausal bleeding; BSO or RSO bilateral or right salpingo-oophorectomy; Rad, radiation therapy; NPR Lymph node dissection not performed or reported; NCF no gross cervical findings; DOC death from other causes; LGSIL low grade squamous intraepithelial lesion; HGSIL high grade squamous intraepithelial lesion; CIN cervical intraepithelial neoplasia. Cases in Cviko et al [8] are excluded due to lack of sufficient clincopathological information; SCC squamous cell carcinoma. **Presumes cases in Grayson et al (1997) are the same in Grayson et al (1999); AWL: acetowhite lesions. NI: information not included due to a lack of sufficient itemization in original manuscript. NA: information not available. *excludes the 4 cases in Grayson et al [9] with "divergent neoplastic epithelial differentiation"; *** follow-up as reported in [23]; @ Unrelated to cervical pathology; ## Includes the cases of microinvasive carcinoma [1,10,20], see text |
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|
Russell and Fadare Diagnostic Pathology 2006 1:18 doi:10.1186/1746-1596-1-18 |
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