Table 1

Previously reported cases of morphologically pure adenoid basal lesions in the English literature.

Authors (reference)

No of patients

age (yrs)

Race

Presentation/pap smear findings

Gross or pelvic examination findings

Associated cervical intraepithelial dysplastic lesion

Diagnostic and/or Therapeutic measure(s)

Lymph node status

Follow-up, (months)


1

Baggish & Woodruff [24]***

1

63

white

Vaginal bleeding/NR

Atrophic vaginal mucosa; NCF

CIS

Hysterectomy/BSO

NPR

NED 156

2

1

62

black

Uterine prolapse/NR

NCF

CIS

Hysterectomy

NPR

NED 84

3

1

39

black

Abnormal pap smear

NR

CIS

Conization/Hysterectomy

NPR

NED 60

4

Baggish & Woodruff [23]

1

60

white

"incidental"/negative

NCF

None

Hysterectomy/BSO

NPR

NED 6

5

Cases 1–3

1

80

white

"incidental"/negative

NCF

None

Hysterectomy/BSO

NPR

NED 6

6

1

80

black

Lower abdominal pressure/negative

Cervical eversion

CIS

Conization/Hysterectomy/BSO

NPR

NED 6

7

Russell & Laverty [22]

1

62

NR

uterine prolapse and vaginal bleeding/"Very Atypical cells"

Cervical ulceration

None

Hysterectomy

NPR

NR

8

Daroca & Dhurandhar [25], Case 3

1

60

NR

Post menopausal bleeding

Cervical erosion

CIS

Hysterectomy/BSO

NPR

NED 12

9–13

van Dinh & Woodrhuff [21]##

5

mean 56

white 3, black 2

Vaginal bleeding n = 1, asymptomatic n = 4/moderate atypia n = 5

Cervical ulceration n = 1, NCF n = 4

CIN3 n = 3, None n = 2

dilatation and curettage n = 1, Hysterectomy +/- BSO n = 4

NPR

DOC n = 1, NED 24–144, n = 4

14

Ferry & Scully [20]

1

69

black

Abnormal pap smear n = 11, PMB n = 2

NCF n = 10, cervical induration n = 2,

CIS

Hysterectomy/BSO

NPR

NED 60

15

Cases 1–13

1

63

NR

CIS

Hysterectomy/BSO

NPR

NED 120

16

1

66

black

CIS

Cervical excision/Rad

NPR

DOC 24

17

1

75

white

CIS

Hysterectomy/BSO

NPR

NED 84

18

1

65

asian

CIS

Hysterectomy/BSO/Rad

NPR

NED 72

19

1

51

NR

CIS

Hysterectomy/BSO

NPR

NED 24

20

1

56

NR

CIS

Cervical excision

NPR

NED 72

21

1

78

white

CIS

Cervical excision

NPR

NED 72

22

1

59

white

CIS

Hysterectomy/RSO

NPR

NED 60

23

1

67

black

CIS

Hysterectomy/BSO

NPR

NED 48

24

1

57

white

CIS

Hysterectomy/BSO

NPR

NED 24

25

1

72

black

CIS

Conization

NPR

NED 29

26

1

57

NR

CIS

NR

NPR

DOC 0

27

Langlois et al [19]

1

59

NR

Asymptomatic/abnormal pap smear

NCF

CIN3

Conization, Hysterectomy

NPR

NR

28

Peterson & Neumann [18]

1

64

other

Asymptomatic/HGSIL

NR

CIN2

Conization

NPR

NR

29

Layton-Henry et al [17]

1

62

NR

Abnormal Pap smear n = 5/HGSIL, one with "possible invasion", n = 3; inconclusive n = 2

NCF

CIN

Conization, Hysterectomy, BSO, LN

Negative

NED 1

30

1

64

NR

NCF

CIN

Conization, Hysterectomy, BSO

NPR

NED 7

31

1

75

NR

NCF

CIN

Conization

NPR

NED 15

32

1

60

NR

NCF

CIN

Conization, Hysterectomy, BSO, LN

Negative

NED 26

33

1

59

NR

NCF

CIN

Conization, Hysterectomy, BSO, LN

Negative

VAIN 16

34

Powers & Frable [16]

1

79

white

Asymptomatic/SCC

AWL

CIS

Conization, Hysterectomy BSO, LN

Negative

NED 18

35

1

67

black

Presentation @/"severely atypical small cells"

NCF

None

Conization, Rad

NPR

NED 16

36–40

Jones et al [13]

1

Mean 51

white n = 5

abnormal pap n = 4, PMB n = 1

"Ulcerated, irregular indurated mass" n = 2, NCF n = 3

CIN 1 to3 (n = 5)

Hysterectomy/BSO (n = 5), Hysterectomy/BSO/LN (n = 4). One patient also received Rad

Negative

NED 26 Mean

41

Yoshida et al [14]

1

49

asian

Asymptomatic

NCF

CIN 3

Hysterectomy

NPR

NR

42–45*

Grayson et al [9] (Cases 4,5,7,8)

4

NI

black

NI

NI

NI

NI

NI

NI

46

Brainard & Hart [10]

1

91

NR

Dysuria, Night sweats/HGSIL

Focal hemorrhage

CIS

Conization

NPR

NED 4

47

1

68

NR

Asymptomatic/HGSIL

NCF

CIS

Conization, Hysterectomy, BSO, LN

Negative

NED 5

48

1

78

NR

Vaginal spotting/HGSIL

NCF

Severe dysplasia

Conization, Hysterectomy, BSO, LN

Negative

NED 15

49

1

30

NR

Asymptomatic/HGSIL

NCF

Moderate severe dysplasia

Conization, Hysterectomy, BSO, LN

Negative

NED 17

50

1

71

NR

Asymptomatic/HGSIL

NCF

CIS

Conization

NPR

NED 21

51

1

67

NR

Asymptomatic/HGSIL

NCF

Microinvasive Carcinoma##

Conization, Hysterectomy, BSO, LN

Negative

NED 28

52

1

70

NR

Dysuria, Hematuria/Negative

NCF

None

Hysterectomy

NPR

NED 30

53

1

72

NR

Asymptomatic/HGSIL

NCF

CIS

Conization, Hysterectomy

NPR

NED 70

54

1

71

NR

Asymptomatic/HGSIL

NCF

CIS

Conization, BSO, Rad, LN

Negative

NED 82

55

1

76

NR

NR/HGSIL

NCF

CIS

Hysterectomy, BSO

NPR

NED 24

56

1

70

NR

Asymptomatic/LGSIL

NCF

CIS

Hysterectomy, Rad

NPR

NED 63

57

1

83

NR

Asymptomatic/HGSIL

NCF

CIS

Conization

NPR

NED 87

58

1

35

NR

Pelvic mass@/Normal

NCF

None

Hysterectomy, BSO, LN, Chemotherapy [all@]

Negative

NED 49

59

1

57

NR

Asymptomatic/CIS

NCF

CIN

Conization

NPR

NED 5

60

1

69

NR

Asymptomatic/abnormal pap smear

NCF

None

Conization

NPR

NR

61

Senzaki et al [11]

1

69

asian

Vaginal bleeding

NCF

CIS

Hysterectomy, BSO, LN [all@]

Negative

NED 6

62

Hiroi et al [6]

1

74

asian

Vaginal bleeding

NCF

CIN 3

Hysterectomy

NPR

NR

63

Khoury et al [4]

1

79

black

Asymptomatic/HGSIL

NCF

Severe dysplasia

Hysterectomy, BSO

NPR

NR

64

Teramoto [2]

1

69

asian

Asymptomatic/HGSIL

NR

CIN3

Hysterectomy and chemotherapy@

NPR

108

65

Zamecnik & Skrivanek [1]

1

21

NR

Asymptomatic//LGSIL

NCF

CIN1-3

Conization

NPR

NED 1

66

Parwani et al [1]

1

65

NR

NR/HGSIL

NR

Microinvasive Carcinoma##

Conization, Hysterectomy, LN

Negative

NED 78


    Abbreviations:
NED, no evidence of disease; CIS, carcinoma in situ; LN, lymph node dissection; N/A, not applicable; PMB postmenopausal bleeding; BSO or RSO bilateral or right salpingo-oophorectomy; Rad, radiation therapy; NPR Lymph node dissection not performed or reported; NCF no gross cervical findings; DOC death from other causes; LGSIL low grade squamous intraepithelial lesion; HGSIL high grade squamous intraepithelial lesion; CIN cervical intraepithelial neoplasia. Cases in Cviko et al [8] are excluded due to lack of sufficient clincopathological information; SCC squamous cell carcinoma. **Presumes cases in Grayson et al (1997) are the same in Grayson et al (1999); AWL: acetowhite lesions. NI: information not included due to a lack of sufficient itemization in original manuscript. NA: information not available. *excludes the 4 cases in Grayson et al [9] with "divergent neoplastic epithelial differentiation"; *** follow-up as reported in [23]; @ Unrelated to cervical pathology; ## Includes the cases of microinvasive carcinoma [1,10,20], see text

Russell and Fadare Diagnostic Pathology 2006 1:18   doi:10.1186/1746-1596-1-18

Open Data